Covers wet granulation, dry granulation, RMG, fluid bed granulation.
Introduction If you’ve ever swallowed a tablet, you’ve probably noticed that it starts working after a certain amount of time. But have you ever wondered what makes a hard compressed tablet break apart quickly once it reaches the stomach? The answer is disintegrants. During my experience in pharmaceutical manufacturing, one of the most common in-process […]
Introduction If you’ve ever worked in a pharmaceutical granulation area, you’ve probably noticed that the active pharmaceutical ingredient (API) is often only a small part of the total tablet weight. The remaining portion is made up of excipients, and among them, diluents play one of the most important roles. Early in my experience working around
Introduction If you have ever worked in a tablet manufacturing area, you know that even a perfectly prepared granule can create serious problems during compression if lubrication is not done correctly. Tablets may stick inside the die, punches may wear quickly, tablet hardness may drop, or dissolution may fail. In many cases, the root cause
In pharmaceutical manufacturing, reducing the size of materials is a common activity. Granules may become too large after drying, powders may contain lumps, and sometimes a material must be resized before it can move to the next manufacturing stage. One commonly used machine for this purpose is the Multi Mill. A Multi Mill is used
Loss on Drying, commonly called LOD, is one of the most frequently checked quality parameters in pharmaceutical manufacturing. If you work in granulation, drying, compression, quality control, or in-process quality assurance, you will hear statements such as: “Check the LOD before unloading the FBD.” “LOD is still high. Continue drying.” “Granules are over-dried.” “LOD is
Introduction Binder addition is one of the most important steps in the wet granulation process. Even if all raw materials are weighed correctly and mixed properly, poor binder addition can result in weak granules, oversized lumps, or tablets that fail during compression. The main purpose of a binder is to hold powder particles together so
Introduction Wet granulation is one of the most commonly used manufacturing processes in the pharmaceutical industry. It helps improve powder flow, increases compressibility, and produces granules that can be compressed into tablets with consistent quality. Because of these advantages, wet granulation is used for many formulations where direct compression is not suitable. In this guide,
Introduction Wet granulation is one of the most widely used pharmaceutical manufacturing techniques for producing high-quality tablets. It improves powder flowability, enhances compressibility, minimizes segregation, and ensures uniform drug distribution throughout the tablet blend. Because of these advantages, the wet granulation process in pharma is preferred for many formulations that cannot be compressed directly. Understanding
Fluid Bed Dryer, commonly called FBD, is one of the most widely used drying equipment in pharmaceutical tablet manufacturing. It is mainly used to dry wet granules after the wet granulation process. Drying may look like a simple operation. Wet granules are loaded, hot air is passed through the material, moisture is removed, and the
🔹 Introduction In pharmaceutical manufacturing, achieving uniform granules is one of the most critical steps for tablet production. If granulation is not controlled properly, it directly affects tablet hardness, dissolution, and content uniformity. This is where the Rapid Mixer Granulator (RMG) plays a vital role. In my experience working in production, RMG is one of