Covers wet granulation, dry granulation, RMG, fluid bed granulation.
In pharmaceutical manufacturing, reducing the size of materials is a common activity. Granules may become too large after drying, powders may contain lumps, and sometimes a material must be resized before it can move to the next manufacturing stage. One commonly used machine for this purpose is the Multi Mill. A Multi Mill is used
Loss on Drying, commonly called LOD, is one of the most frequently checked quality parameters in pharmaceutical manufacturing. If you work in granulation, drying, compression, quality control, or in-process quality assurance, you will hear statements such as: “Check the LOD before unloading the FBD.” “LOD is still high. Continue drying.” “Granules are over-dried.” “LOD is
Introduction Binder addition is one of the most important steps in the wet granulation process. Even if all raw materials are weighed correctly and mixed properly, poor binder addition can result in weak granules, oversized lumps, or tablets that fail during compression. The main purpose of a binder is to hold powder particles together so
Introduction Wet granulation is one of the most commonly used manufacturing processes in the pharmaceutical industry. It helps improve powder flow, increases compressibility, and produces granules that can be compressed into tablets with consistent quality. Because of these advantages, wet granulation is used for many formulations where direct compression is not suitable. In this guide,
Introduction Wet granulation is one of the most widely used pharmaceutical manufacturing techniques for producing high-quality tablets. It improves powder flowability, enhances compressibility, minimizes segregation, and ensures uniform drug distribution throughout the tablet blend. Because of these advantages, the wet granulation process in pharma is preferred for many formulations that cannot be compressed directly. Understanding
Introduction Moisture plays a critical role in pharmaceutical manufacturing. After the wet granulation process, the granules contain excess moisture that must be removed before blending and tablet compression. If the granules are not dried properly, they may stick during compression, cause weight variation, reduce tablet hardness, or affect the stability of the finished product. This
🔹 Introduction In pharmaceutical manufacturing, achieving uniform granules is one of the most critical steps for tablet production. If granulation is not controlled properly, it directly affects tablet hardness, dissolution, and content uniformity. This is where the Rapid Mixer Granulator (RMG) plays a vital role. In my experience working in production, RMG is one of
Quick Answer In-process checks during granulation are quality control checks performed during the granulation process to ensure that the granules meet predefined specifications such as moisture content, particle size, density, and flow properties before moving to the next manufacturing stage. These checks help maintain product quality, batch consistency, and GMP compliance. Pharmaceutical manufacturing processes must
Introduction In pharmaceutical manufacturing, tablet production can be performed using different techniques such as wet granulation, dry granulation, and direct compression. Direct compression in pharma is one of the simplest and fastest methods, where powders are compressed directly into tablets without any granulation step. This process reduces manufacturing time, minimizes moisture exposure, and improves operational
Introduction A single mistake in binder preparation can destroy an entire pharmaceutical batch. Incorrect binder concentration, poor temperature control, or over-wetting during wet granulation can lead to sticking, failed dissolution, weak tablets, and even batch rejection. That is why binder preparation in pharma is considered one of the most critical stages in tablet manufacturing. In