Introduction Sifting is a simple-looking operation, but it is important in pharmaceutical manufacturing. During manufacturing, powders and granules may contain lumps, oversized particles, or foreign particles. Sifting helps separate particles according to size and provides a more uniform material for the next processing step. In the pharma industry, the sieve used for a material should […]
Over Drying vs Under Drying in Pharmaceutical Granules is an important topic because the moisture level of granules can affect drying performance, compression behavior, and overall tablet quality. After wet granulation, the material contains a significant amount of moisture from the granulating solution. This moisture must be removed before the granules can move to the
Every pharmaceutical company receives hundreds of raw materials and packaging materials every day. These materials travel long distances by truck, container, or courier. During transportation, some materials may become damaged due to poor handling, accidents, water leakage, improper stacking, or broken packaging. Receiving damaged material is a serious GMP issue. If damaged material is accepted
Every medicine starts with raw materials and packaging materials. If these materials are received incorrectly, the final product can be affected even before manufacturing begins. That is why material receipt is one of the most critical warehouse activities in every pharmaceutical company. A small mistake, such as accepting a damaged drum, missing COA, incorrect batch
Receiving raw materials is not only about unloading cartons from a vehicle. One of the first and most important GMP activities is verifying the Delivery Challan (DC) and Invoice before accepting the shipment. Many warehouse deviations, inventory mismatches, payment disputes, and audit observations start because these documents were not checked properly. A warehouse person should
Introduction Every medicine reaches the patient safely because of two important things—the quality of the product and the quality of its packaging. Even if a tablet or injection is manufactured perfectly, damaged cartons, incorrect labels, defective bottles, or mixed packaging materials can lead to product recalls, regulatory observations, and patient safety risks. That is why
Every pharmaceutical product begins with raw materials and packaging materials received from suppliers. Even if a supplier is approved, every delivery must be carefully verified before unloading. A single damaged truck, incorrect batch, or broken seal can compromise product quality and patient safety. This is why Vendor Delivery Verification During Material Receipt is one of
Introduction If you’ve ever swallowed a tablet, you’ve probably noticed that it starts working after a certain amount of time. But have you ever wondered what makes a hard compressed tablet break apart quickly once it reaches the stomach? The answer is disintegrants. During my experience in pharmaceutical manufacturing, one of the most common in-process
Introduction If you’ve ever worked in a pharmaceutical granulation area, you’ve probably noticed that the active pharmaceutical ingredient (API) is often only a small part of the total tablet weight. The remaining portion is made up of excipients, and among them, diluents play one of the most important roles. Early in my experience working around
Introduction If you have ever worked in a tablet manufacturing area, you know that even a perfectly prepared granule can create serious problems during compression if lubrication is not done correctly. Tablets may stick inside the die, punches may wear quickly, tablet hardness may drop, or dissolution may fail. In many cases, the root cause