In-Process Checks (IPC) - Pharma GMP Guide

Tablet weight variation IPC check using analytical balance during tablet compression in pharmaceutical manufacturing

Tablet Weight Variation: 11 Common Causes, IPC Checks & GMP Solutions Explained

pharma Gmp Guide / February 21, 2026

Introduction Tablet weight variation is one of the most common in-process problems during pharmaceutical tablet manufacturing. Even a small change in tablet weight can affect drug content uniformity, dissolution, stability, and regulatory compliance. That is why GMP guidelines require strict monitoring through In-Process Checks (IPC) during compression. In real manufacturing environments, weight variation usually indicates […]

In-Process Checks (IPC) in Pharma: Limits, Acceptance Criteria, GMP Checklist & Real Examples

pharma Gmp Guide / February 20, 2026

Introduction In pharmaceutical manufacturing, product quality cannot depend only on final testing. Quality must be monitored during manufacturing itself. This is where In-Process Checks (IPC) become critical. IPC ensures that tablets, capsules, and other dosage forms remain within predefined limits during production. Proper IPC limits and acceptance criteria help prevent batch failure, deviations, and regulatory

Pharmaceutical Production, In-Process Checks (IPC)

In-Process Checks During Tablet Compression: GMP Requirements and Practical Challenges

pharma Gmp Guide / February 3, 2026

Introduction Tablet compression is one of the most critical stages in pharmaceutical manufacturing. Even when granulation and blending are performed correctly, poor control during compression can lead to major quality defects such as weight variation, hardness issues, capping, lamination, and dissolution failure. That is why in-process checks (IPCs) are mandatory under Good Manufacturing Practices (GMP).